Hollywood actor Dennis Quaid has recently been in the news for his new film portrayal of former President Ronald Reagan as well as for his expressed support for former President Donald Trump in the upcoming election.

Yet, during an interview with CNN's Chris Wallace, Quaid was asked about his failed marriage to famed actress Meg Ryan which ended in divorce more than two decades ago amid acts of infidelity by both partners, according to the New York Post's Page Six.

Quaid acknowledged some of the rumors surrounding their troubled relationship but said he had "no regrets" about their time together, if only because it resulted in the son they share, Jack Quaid.

Different levels of stardom strained the relationship

During an appearance on Max's "Who's Talking to Chris Wallace," Quaid opened up about his relationship with Ryan that began in 1987 and led to their marriage in 1991 but revealed that it quickly became strained because of their different levels of stardom at the time and ultimately resulted in a divorce in 2001.

"When I met Meg I was here as far as career thing and she was here and then it just went like that," Quaid said, using his hands to illustrate his ex-wife's surge in popularity. "I tried to be a big person and tell myself that didn’t bother me, but people are human."

That is similar to what Quaid told then-NBC host Megyn Kelly during a 2018 interview when he described his marriage with Ryan as the "most successful relationship of my life."

"When we met, you know, I was the big deal," he said at the time. "Then we would go out on the streets of New York, and people would be like, 'Meg! Meg!' I have to admit it, I actually did feel like I disappeared. I didn't think I was that small, but I was."

In his interview with Wallace, Quaid explained how as Ryan's career was "ascending," his career was stalled out amid a drug addiction that sent him "into rehab," which put a damper on their time together.

"Meg is really such a great, sweet person and really talented and deserved all her success," he said. "I don’t regret anything about my marriage to Meg. We got Jack Quaid out of it who is really going on to maybe eclipse both of us."

Ryan and Russell Crowe

Page Six reported that Quaid and Ryan were viewed as a Hollywood "power couple" throughout the 1990s but that they were separated in 2000 and then divorced in 2001 while Ryan was rumored to be in a relationship with rising Hollywood star Russell Crowe.

For her part, however, according to Honey, Ryan insisted in a 2006 interview with Oprah Winfrey that her marriage to Quaid was already "unhealthy" before she hooked up with Crowe and that, despite what the tabloids said at the time, the Australian actor played no role in the dissolution of that relationship, and said, "I didn't leave my marriage for Russell Crowe. I left my marriage."

She reiterated that point in a 2008 interview with InStyle, when Ryan confirmed that "Russell didn't break up the marriage. He was definitely there at the end, but it wasn't his fault. I was a mess. I hurt him, too, at the end. I couldn't be in another long relationship, it wasn't the time for that. So I got out."

Ryan revealed Quaid was unfaithful too

In that 2008 InStyle interview, Ryan further revealed that Quaid had previously cheated on her during their marriage, and said at the time, "Dennis was not faithful to me for a long time, and that was very painful. I found out more about that once I was divorced."

Initially, Quaid was upset with his ex-wife for continuing to "publicly rehash and rewrite the story" of their break-up, especially given how traumatic it was for their son, but he eventually came to peace with it.

Ryan never did get married again, though she dated singer John Mellencamp for about a decade, while Quaid went on to marry in 2004 his third wife, actress Kimberly Buffington, with whom he has twin daughters, before also divorcing her and marrying his fourth wife, Laura Savoie, in 2020.